Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects

Abstract Thrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to human health life. Because antithrombotic drugs can prevent beginning progression thrombotic disorders, they are essential in management diseases. The substantial side effects unsatisfactory efficacy present stimulate search for novel, effective, safer therapies. Natural synthetic coumarins have been shown action, specifically anticoagulation, antiplatelet aggregation. In particular, coumarin-based medications like warfarin, phenprocoumon, cloricromen long used treat thrombosis clinical settings. favored structure creating novel with diverse modes action coumarin, which has low toxicity. goal current review consolidate recent findings on development as agents, focus connection between these compounds’ chemical compositions therapeutic potency. It aims offer promising suggestions identification new coumarin compounds potent properties.